Prions can infect primary cultured neurons and astrocytes and promote neuronal cell death.

  title={Prions can infect primary cultured neurons and astrocytes and promote neuronal cell death.},
  author={Sabrina Cronier and Hubert Laude and Jean-Michel Peyrin},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={101 33},
Transmissible spongiform encephalopathies arise as a consequence of infection of the central nervous system by prions, where neurons and glial cells are regarded as primary targets. Neuronal loss and gliosis, associated with the accumulation of misfolded prion protein (PrP), are hallmarks of prion diseases; yet the mechanisms underlying such disorders remain unclear. Here we introduced a cell system based on primary cerebellar cultures established from transgenic mice expressing ovine PrP and… CONTINUE READING
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