Prions as adaptive conduits of memory and inheritance

@article{Shorter2005PrionsAA,
  title={Prions as adaptive conduits of memory and inheritance},
  author={James Shorter and Susan Lindquist},
  journal={Nature Reviews Genetics},
  year={2005},
  volume={6},
  pages={435-450}
}
Changes in protein conformation drive most biological processes, but none have seized the imagination of scientists and the public alike as have the self-replicating conformations of prions. Prions transmit lethal neurodegenerative diseases by means of the food chain. However, self-replicating protein conformations can also constitute molecular memories that transmit genetic information. Here, we showcase definitive evidence for the prion hypothesis and discuss examples in which prion-encoded… Expand
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