• DOI:10.1038/nrg1616
Corpus ID: 5575951

Prions as adaptive conduits of memory and inheritance

@article{Shorter2005PrionsAA,
  title={Prions as adaptive conduits of memory and inheritance},
  author={J. Shorter and S. Lindquist},
  journal={Nature Reviews Genetics},
  year={2005},
  volume={6},
  pages={435-450}
}

J. Shorter, S. Lindquist

Published 2005

Biology, Medicine

Nature Reviews Genetics

Changes in protein conformation drive most biological processes, but none have seized the imagination of scientists and the public alike as have the self-replicating conformations of prions. Prions transmit lethal neurodegenerative diseases by means of the food chain. However, self-replicating protein conformations can also constitute molecular memories that transmit genetic information. Here, we showcase definitive evidence for the prion hypothesis and discuss examples in which prion-encoded… CONTINUE READING

View on Springer

lindquistlab.wi.mit.edu

Save to Library

Create Alert

Cite

Launch Research Feed