Prions as adaptive conduits of memory and inheritance

  title={Prions as adaptive conduits of memory and inheritance},
  author={J. Shorter and S. Lindquist},
  journal={Nature Reviews Genetics},
  • J. Shorter, S. Lindquist
  • Published 2005
  • Biology, Medicine
  • Nature Reviews Genetics
  • Changes in protein conformation drive most biological processes, but none have seized the imagination of scientists and the public alike as have the self-replicating conformations of prions. Prions transmit lethal neurodegenerative diseases by means of the food chain. However, self-replicating protein conformations can also constitute molecular memories that transmit genetic information. Here, we showcase definitive evidence for the prion hypothesis and discuss examples in which prion-encoded… CONTINUE READING
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