Prions are a common mechanism for phenotypic inheritance in wild yeasts

  title={Prions are a common mechanism for phenotypic inheritance in wild yeasts},
  author={Randal Halfmann and Daniel F Jarosz and Sandra K. Jones and Amelia Chang and Alex K Lancaster and Susan Lindquist},
The self-templating conformations of yeast prion proteins act as epigenetic elements of inheritance. Yeast prions might provide a mechanism for generating heritable phenotypic diversity that promotes survival in fluctuating environments and the evolution of new traits. However, this hypothesis is highly controversial. Prions that create new traits have not been found in wild strains, leading to the perception that they are rare ‘diseases’ of laboratory cultivation. Here we biochemically test… CONTINUE READING
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