Prions and the immune system: a journey through gut, spleen, and nerves.

@article{Aguzzi2003PrionsAT,
  title={Prions and the immune system: a journey through gut, spleen, and nerves.},
  author={Adriano Aguzzi},
  journal={Advances in immunology},
  year={2003},
  volume={81},
  pages={123-71}
}
For more than two decades it has been contended that prion infection does not elicit immune responses: transmissible spongiform encephalopathies do not go along with conspicuous inflammatory infiltrates, and antibodies to the prion protein are typically undetectable. Why is it, then, that prions accumulate in lymphoid organs, and that various states of immune deficiency prevent peripheral prion infection? This review revisits the current evidence of the involvement of the immune system in prion… CONTINUE READING

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