Prions and prion proteins.

  title={Prions and prion proteins.},
  author={N Stahl and Stanley B Prusiner},
  journal={FASEB journal : official publication of the Federation of American Societies for Experimental Biology},
  volume={5 13},
Neurodegenerative diseases of animals and humans including scrapie, bovine spongiform encephalopathy, and Creutzfeldt-Jakob disease are caused by unusual infectious pathogens called prions. There is no evidence for a nucleic acid in the prion, but diverse experimental results indicate that a host-derived protein called PrPSc is a component of the infectious particle. Experiments with scrapie-infected cultured cells show that PrPSc is derived from a normal cellular protein called PrPC through an… CONTINUE READING
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