Prions and peripheral nerves: a deadly rendezvous.

  title={Prions and peripheral nerves: a deadly rendezvous.},
  author={Mathias Heikenwalder and Christian Julius and Adriano Aguzzi},
  journal={Journal of neuroscience research},
  volume={85 12},
The infectious particle causing transmissible spongiform encephalopathy (TSE), a fatal neurodegenerative disease of humans and animals, has been termed prion. Its major component is an aggregated variant of the cellular prion protein, PrP(C). The main target of prion pathology is the central nervous system (CNS), yet most prion diseases are initiated or… CONTINUE READING