Prions and nucleic acids: search for "residual" nucleic acids and screening for mutations in the PrP-gene.

@article{Riesner1993PrionsAN,
  title={Prions and nucleic acids: search for "residual" nucleic acids and screening for mutations in the PrP-gene.},
  author={Detlev Riesner and Klaus Kellings and U Wiese and Michael Wulfert and C A Mirenda and Stanley B Prusiner},
  journal={Developments in biological standardization},
  year={1993},
  volume={80},
  pages={
          173-81
        }
}
Studies on prions involve nucleic acid chemistry under two headings: i) do infectious prion particles contain nucleic acids? ii) is it possible by a simple procedure to screen the prion protein (PrP)-gene for mutations? The return refocusing gel electrophoresis technique was developed to detect by sensitive silver staining homogeneous and heterogeneous nucleic acids extracted from highly purified scrapie prion preparations. With this method all kinds of nucleic acids from a length of 13… CONTINUE READING
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