Prions and blood products

@article{Foster2000PrionsAB,
  title={Prions and blood products},
  author={Peter R Foster},
  journal={Annals of Medicine},
  year={2000},
  volume={32},
  pages={501 - 513}
}
The transmission of Creutzfeldt-Jakob disease (CJD) by human pituitary-derived growth hormone has led to concerns that blood products might also provide a route for the iatrogenic transmission of CJD. A number of actions have been implemented by regulatory authorities to address such concerns, and numerous studies have been undertaken to determine whether or not there is a risk of CJD being transmitted in this manner. To date, no excess risk has been identified, leading to a growing consensus… 

Variant Creutzfeldt-Jakob disease and blood transfusion

  • M. Turner
  • Medicine
    Current opinion in hematology
  • 2001
In the face of uncertainty surrounding the risk of transmission of vCJD by blood products, blood transfusion services in a number of countries have implemented precautionary policies, though whether in the long term these will prove to have been necessary or sufficient remains to be seen.

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  • N. PedersenElse Smith
  • Biology, Medicine
    APMIS : acta pathologica, microbiologica, et immunologica Scandinavica
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CJD caused by infections involves either iatrogenic cases of CJD, resulting from exposure to infectious brain, pituitary or ocular tissue, or from ingestion of infected food items, and the size of the epidemic is still unclear and worst‐case scenarios indicate that many thousands of cases in the future are expected.

Prions in dermatology.

  • O. Lupi
  • Medicine
    Journal of the American Academy of Dermatology
  • 2002
Although bovine collagen has long been recognized as a safe and biocompatible material, dermatologists should be aware of the theoretical potential for prion transmission when materials from bovines origin and products obtained from cultured cells fed with fetal or newborn calf serum are used.

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The degree to which prion agents might be eliminated during the manufacture of plasma derivatives is of considerable interest to manufacturers, clinicians, and patients, and established manufacturing processes were examined.

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VCJD has now been reported in non-UK countries, as has BSE, and the prion hypothesis proposes that the infective agent in TSEs is a misfolded form of pion protein that can be generated from the normal form of the protein present in many tissues of the body, by the action of PrPsc.

Bovine Spongiform Encephalopathy An Updated Scientific Literature Review

Variant CJD cases continue to be diagnosed in the UK but the rate of increase in cases is not increasing, leading some experts to revise downward predictions of the future extent of the epidemic.

Partitioning of TSE infectivity during ethanol fractionation of human plasma.

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