Prions and blood products

  title={Prions and blood products},
  author={Peter R Foster},
  journal={Annals of Medicine},
  pages={501 - 513}
The transmission of Creutzfeldt-Jakob disease (CJD) by human pituitary-derived growth hormone has led to concerns that blood products might also provide a route for the iatrogenic transmission of CJD. A number of actions have been implemented by regulatory authorities to address such concerns, and numerous studies have been undertaken to determine whether or not there is a risk of CJD being transmitted in this manner. To date, no excess risk has been identified, leading to a growing consensus… 

Variant Creutzfeldt-Jakob disease and blood transfusion

  • M. Turner
  • Medicine
    Current opinion in hematology
  • 2001
In the face of uncertainty surrounding the risk of transmission of vCJD by blood products, blood transfusion services in a number of countries have implemented precautionary policies, though whether in the long term these will prove to have been necessary or sufficient remains to be seen.

Prion diseases: Epidemiology in man

  • N. PedersenElse Smith
  • Biology, Medicine
    APMIS : acta pathologica, microbiologica, et immunologica Scandinavica
  • 2002
CJD caused by infections involves either iatrogenic cases of CJD, resulting from exposure to infectious brain, pituitary or ocular tissue, or from ingestion of infected food items, and the size of the epidemic is still unclear and worst‐case scenarios indicate that many thousands of cases in the future are expected.

Prions in dermatology.

  • O. Lupi
  • Medicine
    Journal of the American Academy of Dermatology
  • 2002
Although bovine collagen has long been recognized as a safe and biocompatible material, dermatologists should be aware of the theoretical potential for prion transmission when materials from bovines origin and products obtained from cultured cells fed with fetal or newborn calf serum are used.

Plasma products and prion removal: “Is you is or is you ain't …?”

The degree to which prion agents might be eliminated during the manufacture of plasma derivatives is of considerable interest to manufacturers, clinicians, and patients, and established manufacturing processes were examined.

A report on transmissible spongiform encephalopathies and transfusion safety

This report of the International Society of Blood Transfusion Working Party on Transmissible Spongiform Encephalopathy will focus on the state of the art in relation to blood components and plasma safety.

Mad Cows and Englishmen: An Update on Blood and vCJD

VCJD has now been reported in non-UK countries, as has BSE, and the prion hypothesis proposes that the infective agent in TSEs is a misfolded form of pion protein that can be generated from the normal form of the protein present in many tissues of the body, by the action of PrPsc.

Bovine Spongiform Encephalopathy An Updated Scientific Literature Review

Variant CJD cases continue to be diagnosed in the UK but the rate of increase in cases is not increasing, leading some experts to revise downward predictions of the future extent of the epidemic.

Partitioning of TSE infectivity during ethanol fractionation of human plasma.

  • L. GregoriJ. Maring R. Rohwer
  • Biology, Medicine
    Biologicals : journal of the International Association of Biological Standardization
  • 2004



Can Creutzfeldt-Jakob disease be transmitted by transfusion?

  • P. Brown
  • Medicine, Biology
    Current opinion in hematology
  • 1995
Epidemiologic studies do not support the contention that the administration of blood, blood components, or blood derivatives transmits the disease, and it will require an unremitting effort to screen from the blood donor population all individuals with a higher than average risk of harboring the infectious agent.

The risk of blood-borne Creutzfeldt--Jakob disease.

  • P. Brown
  • Medicine, Biology
    Developments in biologicals
  • 2000
Data from rodent studies should provide a rational foundation for policy decisions by government agencies, plasma product manufacturers, and blood banking communities about the possible risks of transmitting CJD through the administration of blood or plasma products.

Prion protein and developments in its detection

Prion protein in an abnormal conformation has been identified as inextricably linked with the infectivity of transmissible spongiform encephalopathies such as vCJD and in this review some of its properties relevant to its detection are considered.

Variant Creutzfeldt-Jakob Disease

INTRODUCTION Creutzfeldt–Jakob Disease (CJD) has been the focus of much attention in recent years due to the identification of a new variant now known as variant CJD (vCJD). Experimental evidence has

Retrospective neuropathological review of prion disease in UK haemophilic patients.

It is concluded that, at present, there is no evidence for the transmission of nvCJD via clotting factor concentrate to patients with haemophilia.

New variant Creutzfeldt-Jakob disease and bovine spongiform encephalopathy.

17 Biosafety Issues in Prion Diseases

Biosafety relevant to prions has been addressed in several guidelines and recommendations published by health authorities in an attempt to limit the potential risk associated with prion contamination in laboratory studies as well as in foods and medicinal products, but prion diseases still are treated as viral-like diseases.

Creutzfeldt-Jakob disease and blood transfusion.

There seems to be a safe threshold at 20-30% of the normal serum a, antitrypsin concentration, implying that replacement treatment should logically be reserved for those with type ZZ, but the possibility of antenatal diagnosis is relevant only in the context of neonatal hepatitis.