Prion strain-dependent differences in conversion of mutant prion proteins in cell culture.

@article{Atarashi2006PrionSD,
  title={Prion strain-dependent differences in conversion of mutant prion proteins in cell culture.},
  author={Ryuichiro Atarashi and Valerie L Sim and Noriyuki Nishida and Byron Caughey and Shigeru Katamine},
  journal={Journal of virology},
  year={2006},
  volume={80 16},
  pages={7854-62}
}
Although the protein-only hypothesis proposes that it is the conformation of abnormal prion protein (PrP(Sc)) that determines strain diversity, the molecular basis of strains remains to be elucidated. In the present study, we generated a series of mutations in the normal prion protein (PrP(C)) in which a single glutamine residue was replaced with a basic amino acid and compared their abilities to convert to PrP(Sc) in cultured neuronal N2a58 cells infected with either the Chandler or 22L mouse… CONTINUE READING
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