Prion proteins: physiological functions and role in neurological disorders.

@article{Hu2008PrionPP,
  title={Prion proteins: physiological functions and role in neurological disorders.},
  author={Wei Hu and Bernd C. Kieseier and Elliot M. Frohman and Todd N Eagar and Roger N. Rosenberg and H C Hartung and Olaf St{\"u}ve},
  journal={Journal of the neurological sciences},
  year={2008},
  volume={264 1-2},
  pages={1-8}
}
Stanley Prusiner was the first to promote the concept of misfolded proteins as a cause for neurological disease. It has since been shown by him and other investigators that the scrapie isoform of prion protein (PrP(Sc)) functions as an infectious agent in numerous human and non-human disorders of the central nervous system (CNS). Interestingly, other organ systems appear to be less affected, and do not appear to lead to major co-morbidities. The physiological function of the endogenous cellular… CONTINUE READING