Prion protein with an E200K mutation displays properties similar to those of the cellular isoform PrP(C).

@article{Rosenmann2001PrionPW,
  title={Prion protein with an E200K mutation displays properties similar to those of the cellular isoform PrP(C).},
  author={Hanna Rosenmann and Galit Talmor and M. Halimi and Amiel Yanai and Ruth Gabizon and Zeev Meiner},
  journal={Journal of neurochemistry},
  year={2001},
  volume={76 6},
  pages={
          1654-62
        }
}
Creutzfeldt-Jakob disease (CJD) in Libyan Jews, linked to the E200K mutation in PRNP (E200KCJD), is the most prevalent of the inherited prion diseases. As other prion diseases, E200KCJD is characterized by the brain accumulation of PrP(Sc), a pathologic conformational isoform of a normal glycoprotein denominated PrP(C). To investigate whether the E200K mutation is enough to de novo confer PrP(Sc) properties to mutant PrP, as suggested by experiments in Chinese hamster ovary cells, we examined… CONTINUE READING
BETA

Citations

Publications citing this paper.
SHOWING 1-10 OF 15 CITATIONS

Similar Papers

Loading similar papers…