Prion protein remodelling confers an immediate phenotypic switch

Abstract

In a variety of systems, proteins have been linked to processes historically limited to nucleic acids, such as infectivity and inheritance. These atypical proteins, termed prions, lack sequence homology but are collectively defined by their capacity to adopt multiple physical and therefore functional states in vivo. Newly synthesized prion protein generally… (More)
DOI: 10.1038/nature03981

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