Prion protein gene polymorphisms in natural goat scrapie.

@article{Billinis2002PrionPG,
  title={Prion protein gene polymorphisms in natural goat scrapie.},
  author={Charalambos Billinis and Cynthia H. Panagiotidis and Vassilios Psychas and Stamatis Argyroudis and Anna Nicolaou and Sotirios Leontides and Orestis Papadopoulos and Theodoros Sklaviadis},
  journal={The Journal of general virology},
  year={2002},
  volume={83 Pt 3},
  pages={713-21}
}
A total of 51 goats, including seven clinical cases, from the first herd in Greece reported to have scrapie was examined to discern an association between scrapie susceptibility and polymorphisms of the gene encoding the prion protein (PrP). Each animal was evaluated for clinical signs of the disease, histopathological lesions associated with scrapie, the presence of detectable protease-resistant PrP in the brain and PrP genotype. Eleven different PrP genotypes encoding at least five unique… CONTINUE READING
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