Prion protein expression level alters regional copper, iron and zinc content in the mouse brain.

@article{Pushie2011PrionPE,
  title={Prion protein expression level alters regional copper, iron and zinc content in the mouse brain.},
  author={M Jake Pushie and Ingrid J. Pickering and Gary R Martin and Shigeki Tsutsui and Frank Robert Jirik and Graham N George},
  journal={Metallomics : integrated biometal science},
  year={2011},
  volume={3 2},
  pages={206-14}
}
The central role of the prion protein (PrP) in a family of fatal neurodegenerate diseases has garnered considerable research interest over the past two decades. Moreover, the role of PrP in neuronal development, as well as its apparent role in metal homeostasis, is increasingly of interest. The host-encoded form of the prion protein (PrP(C)) binds multiple copper atoms via its N-terminal domain and can influence brain copper and iron levels. The importance of PrP(C) to the regulation of brain… CONTINUE READING

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