Prion protein conversion in vitro

@article{Supattapone2004PrionPC,
  title={Prion protein conversion in vitro},
  author={Surachai Supattapone},
  journal={Journal of Molecular Medicine},
  year={2004},
  volume={82},
  pages={348-356}
}
  • S. Supattapone
  • Published 2004
  • Biology, Medicine
  • Journal of Molecular Medicine
The infectious agents of prion diseases are composed primarily of an infectious protein designated PrPSc. In cells infected with prions, a host glycoprotein termed PrPC undergoes induced conformational change to PrPSc, but the molecular mechanism underlying this structural transition occurs remains unknown. The prion-seeded conversion of PrPC to protease-resistant PrPSc-like molecules (PrPres) has been studied both in crude and purified in vitro systems in order to investigate the mechanism of… Expand
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