Prion protein and metal interaction: physiological and pathological implications.

@article{Singh2010PrionPA,
  title={Prion protein and metal interaction: physiological and pathological implications.},
  author={Neena Singh and Dola Das and Ajay K. Singh and M. V. N. L. R. Mohan},
  journal={Current issues in molecular biology},
  year={2010},
  volume={12 2},
  pages={
          99-107
        }
}
Metal induced free radicals are important mediators of neurotoxicity in several neurodegenerative conditions such as Alzheimer's disease, Parkinson's disease, and Huntington's disease. Similar evidence is now emerging for prion diseases, a group of neurodegenerative disorders of humans and animals. The main pathogenic agent in all prion disorders is PrP-scrapie (PrP(Sc)), a beta-sheet rich isoform of a normal cell surface glycoprotein known as the prion protein (PrP(C)). Deposits of PrP(Sc) in… CONTINUE READING

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