Prion protein allele A136H154Q171 is associated with high susceptibility to scrapie in purebred and crossbred German Merinoland sheep

@article{Lhken2004PrionPA,
  title={Prion protein allele A136H154Q171 is associated with high susceptibility to scrapie in purebred and crossbred German Merinoland sheep},
  author={Gesine L{\"u}hken and Anne Buschmann and Martin H Groschup and Georg Erhardt},
  journal={Archives of Virology},
  year={2004},
  volume={149},
  pages={1571-1580}
}
Prion protein (PrP) genotypes were determined in eight sheep that have been tested positive for atypical scrapie from purebred or crossbred Merinoland sheep flocks in Germany and compared with the PrP genotypes of their flock mates. Two restriction fragment length polymorphism (RFLP) analyses were developed to determine all PRNP haplotypes occurring by variations at codons 136, 154 and 171. At least one copy of the A136H154Q171 (AHQ) allele was found in all scrapie-positive sheep while the… CONTINUE READING
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