Prion protein affects Ca2+-activated K+ currents in cerebellar purkinje cells.

@article{Herms2001PrionPA,
  title={Prion protein affects Ca2+-activated K+ currents in cerebellar purkinje cells.},
  author={Jochen Herms and Tobias Tings and Stephan Dunker and Hans A. Kretzschmar},
  journal={Neurobiology of disease},
  year={2001},
  volume={8 2},
  pages={324-30}
}
The prion protein (PrPC) has a primary role in the pathogenesis of transmissible spongiform encephalopathies. Its physiological function is not known yet. Altered late afterhyperpolarization has been observed in hippocampal CA1 pyramidal cells of prion protein-deficient mice (Prnp(0/0) mice) presumably caused by a disruption of Ca2+-activated K+ currents. An alteration of these currents has been recently described in scrapie-infected animals, and loss of function of PrPC has been put forward as… CONTINUE READING

From This Paper

Topics from this paper.

Citations

Publications citing this paper.
Showing 1-10 of 26 extracted citations

Similar Papers

Loading similar papers…