Prion protein M129V polymorphism affects retrieval-related brain activity

  title={Prion protein M129V polymorphism affects retrieval-related brain activity},
  author={Andreas Buchmann and Christian R. A. Mondadori and J{\"u}rgen H{\"a}nggi and Amanda Aerni and Pascal Vrti{\vc}ka and Roger Luechinger and Peter Boesiger and Christoph Hock and Roger M. Nitsch and Dominique J.-F. de Quervain and Andreas Papassotiropoulos and Katharina Henke},
The prion protein Met129Val polymorphism has recently been related to human long-term memory with carriers of either the 129MM or the 129MV genotype recalling 17% more words than 129(VV) carriers at 24h following learning. Here, we sampled genotype differences in retrieval-related brain activity at 30min and 24h following learning. Furthermore, genotype groups were compared regarding grey matter concentrations and cognitive profiles. We used event-related functional magnetic resonance imaging… Expand
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  • M. Egan, R. Straub, +14 authors D. Weinberger
  • Biology, Medicine
  • Proceedings of the National Academy of Sciences of the United States of America
  • 2004
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