Prion protein M129V polymorphism affects retrieval-related brain activity

  title={Prion protein M129V polymorphism affects retrieval-related brain activity},
  author={Andreas Buchmann and Christian R. A. Mondadori and J{\"u}rgen H{\"a}nggi and Amanda Aerni and Pascal Vrti{\vc}ka and Roger Luechinger and Peter Boesiger and Christoph Hock and Roger M. Nitsch and Dominique J.-F. de Quervain and Andreas Papassotiropoulos and Katharina Henke},

Prion Protein Gene M129V Polymorphism and Variability in Age at Migraine Onset

The data suggest that the PRNP 129VV polymorphism is not a direct migraine risk factor but is significantly associated with an earlier onset of the disease.

Analysis of single nucleotide polymorphisms of PRNP gene in twenty-four ethnic groups of India

The baseline allele and genotype frequency of four PRNP SNPs including rs1799990 among 24 ethnic groups representing the Indian population are established and the allele andgenotype frequencies are found to be different among different ethnic groups.

Behavioural and Neural Correlates of Individual Differences in Episodic Memory

The present studies provide a starting point for exploring individual differences in the real-life expression of memory; which is more complex, multifaceted and has longer retention intervals, than laboratory memory (LM), thus allowing for the assessment of remote memory.

Systematic investigation of predicted effect of nonsynonymous SNPs in human prion protein gene: a molecular modeling and molecular dynamics study

This procedure would enable researchers to select outstanding candidates for extensive MD simulations in order to decipher more details of HuPrP aggregation and elucidates the obvious relationship between predicted values of aggregation-related nsSNPs in HuPrp gene and molecular modeling and MD simulations results.

Functional MRI Studies of Memory in Aging, Mild Cognitive Impairment, and Alzheimer’s Disease

Brain-behavior studies using a variety of approaches from lesion-based research to functional magnetic resonance imaging (fMRI) demonstrate distinct though highly interrelated neural circuitry for episodic, semantic, and working memory.

What did you do yesterday? A meta-analysis of sex differences in episodic memory.

Results suggest that men may use their spatial advantage in spatially demanding episodic memory tasks, whereas women do well in episodic memories that are verbalizable and tasks that are neither verbal nor spatial, such as remembering faces and odors/tastes/colors.

Genes to Remember Imaging genetics of hippocampus-based memory functions

In the field of imaging genetics, brain function and structure are used as intermediate phenotypes between genes and cognition/diseases to validate and extend findings from behavioral genetics. In ...

KIBRA Polymorphism Is Related to Enhanced Memory and Elevated Hippocampal Processing

These findings link enhanced memory performance in KIBRA T allele carriers to elevated hippocampal functioning, rather than to neural compensation in noncarriers.



The prion gene is associated with human long-term memory.

A role for the prion protein in the formation of long-term memory in humans is suggested after carriers of either the 129MM or the 129MV genotype recalled 17% more information than 129VV carriers, but short- term memory was unaffected.

Calmodulin-binding transcription activator 1 (CAMTA1) alleles predispose human episodic memory performance.

An ultra-high-density genome-wide screen at > 500 000 single nucleotide polymorphisms in a sample of normal young adults stratified for performance on an episodic recall memory test suggested a role for CAMTA1 in human episodic memory.

Better Memory and Neural Efficiency in Young Apolipoprotein E ε4 Carriers

It is suggested that APOE epsilon4 is associated with good episodic memory and an economic use of memory-related neural resources in young, healthy humans.

Patterns of brain activation in people at risk for Alzheimer's disease.

Patterns of brain activation during tasks requiring memory differ depending on the genetic risk of Alzheimer's disease and may predict a subsequent decline in memory.

Variation in GRM3 affects cognition, prefrontal glutamate, and risk for schizophrenia.

  • M. EganR. Straub D. Weinberger
  • Psychology, Biology
    Proceedings of the National Academy of Sciences of the United States of America
  • 2004
GRM3, a metabotropic glutamate receptor-modulating synaptic glutamate, is a promising schizophrenia candidate gene. In a family-based association study, a common GRM3 haplotype was strongly

Increased brain activation during working memory in cognitively intact adults with the APOE ε4 allele

To determine whether brain activation patterns associated with working memory differ as a function of apolipoprotein E (APOE) genotype in cognitively intact adults, an auditory verbal N-back task was employed to probe working memory-related brain activity.

fMRI evidence of compensatory mechanisms in older adults at genetic risk for Alzheimer disease

Results are consistent with a compensatory hypothesis wherein older adults at genetic risk for Alzheimer disease by virtue of the APOE ε4 allele appear to require additional cognitive effort to achieve comparable performance levels on tests of episodic memory encoding.

Homozygous prion protein genotype predisposes to sporadic Creutzfeldt–Jakob disease

It is argued that homozygosity predisposes towards sporadic CJD and that this directly supports the hypothesis that interaction between prion protein molecules underlies the disease process.