Prion protein — mediator of toxicity in multiple proteinopathies

@article{Ayers2020PrionP,
  title={Prion protein — mediator of toxicity in multiple proteinopathies},
  author={Jacob I. Ayers and Stanley B. Prusiner},
  journal={Nature Reviews Neurology},
  year={2020},
  volume={16},
  pages={187-188}
}
A new study shows that interactions of the cellular prion protein with amyloid-β, tau and α-synuclein oligomers are important in mediating the toxicity of these proteins in Alzheimer disease and Parkinson disease. The findings suggest a shared pathway that could be a therapeutic target common to multiple neurodegenerative diseases. 
2 Citations
Collusion of α-Synuclein and Aβ aggravating co-morbidities in a novel prion-type mouse model
TLDR
Novel and unexpected interplays between α-synuclein pathology, Aβ and neuroinflammation in mice that recapitulate the pathology of Alzheimer’s disease and Lewy body dementia are revealed. Expand
Challenges and Advances in Antemortem Diagnosis of Human Transmissible Spongiform Encephalopathies
TLDR
The RT-QuIC assay stands out for its ability to detect PrPSc in cerebrospinal fluid, olfactory mucosa, and dermatome skin samples with high sensitivity and specificity, and the techniques employed for definite diagnosis, as well as the clinical and paraclinical methods for possible and probable diagnosis. Expand

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