Prion protein: a pattern recognition receptor for viral components and uric acid responsible for the induction of innate and adaptive immunity.

Abstract

Prion protein, known as Prp(c), is a GPI-anchored membrane bound glycoprotein ubiquitously expressed in the body. To date, the precise nature of its physiological role remains a mystery. The prion protein's presence on neurons and immune effector cells suggests a dual neurological and immunological function. Some consensus exists regarding the proposed… (More)

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