Prion properties of the Sup35 protein of yeast Pichia methanolica.

  title={Prion properties of the Sup35 protein of yeast Pichia methanolica.},
  author={Vitaly V. Kushnirov and Natalia V. Kochneva-Pervukhova and Maria B. Chechenova and Natalya S Frolova and Michael D. Ter-Avanesyan},
  journal={The EMBO journal},
  volume={19 3},
The Sup35 protein (Sup35p) of Saccharomyces cerevisiae is a translation termination factor of the eRF3 family. The proteins of this family possess a conservative C-terminal domain responsible for translation termination and N-terminal extensions of different structure. The N-terminal domain of Sup35p defines its ability to undergo a heritable prion-like conformational switch, which is manifested as the cytoplasmically inherited [PSI(+)] determinant. Here, we replaced the N-terminal domain of S… CONTINUE READING

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