Prion propagation in mice expressing human and chimeric PrP transgenes implicates the interaction of cellular PrP with another protein

@article{Telling1995PrionPI,
  title={Prion propagation in mice expressing human and chimeric PrP transgenes implicates the interaction of cellular PrP with another protein},
  author={Glenn C Telling and Michael H. Scott and James A. Mastrianni and Ruth Gabizon and Marilyn Torchia and Fred E. Cohen and Stephen J. DeArmond and Stanley B. Prusiner},
  journal={Cell},
  year={1995},
  volume={83},
  pages={79-90}
}
Transgenic (Tg) mice expressing human (Hu) and chimeric prion protein (PrP) genes were inoculated with brain extracts from humans with inherited or sporadic prion disease to investigate the mechanism by which PrPC is transformed into PrPSc. Although Tg(HuPrP) mice expressed high levels of HuPrPC, they were resistant to human prions. They became susceptible to human prions upon ablation of the mouse (Mo) PrP gene. In contrast, mice expressing low levels of the chimeric transgene were susceptible… Expand
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