Prion propagation and toxicity in vivo occur in two distinct mechanistic phases

  title={Prion propagation and toxicity in vivo occur in two distinct mechanistic phases},
  author={M. Sandberg and H. Al-Doujaily and Bernadette Sharps and A. R. Clarke and J. Collinge},
  • M. Sandberg, H. Al-Doujaily, +2 authors J. Collinge
  • Published 2011
  • Biology, Medicine
  • Nature
  • Mammalian prions cause fatal neurodegenerative conditions including Creutzfeldt–Jakob disease in humans and scrapie and bovine spongiform encephalopathy in animals. Prion infections are typically associated with remarkably prolonged but highly consistent incubation periods followed by a rapid clinical phase. The relationship between prion propagation, generation of neurotoxic species and clinical onset has remained obscure. Prion incubation periods in experimental animals are known to vary… CONTINUE READING
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