Prion peptide-mediated cellular prion protein overexpression and neuronal cell death can be blocked by aspirin treatment.

@article{Jeong2011PrionPC,
  title={Prion peptide-mediated cellular prion protein overexpression and neuronal cell death can be blocked by aspirin treatment.},
  author={J Y Jeong and Myung-Hee Moon and J G Seol and Jae-Suk Seo and You-Jin Lee and Sang-Youel Park},
  journal={International journal of molecular medicine},
  year={2011},
  volume={27 5},
  pages={689-93}
}
Prion diseases are infectious neurodegenerative disorders characterized by the conversion of the cellular prion protein (PrPc) to the misfolded isoform (PrPsc). Prion peptide PrP 106-126 [PrP (106-126)] shares many physiological properties with PrPsc; it is neurotoxic in vitro and in vivo. PrP (106-126) induces neurotoxicity by the overexpression of PrPc and activation of the mitogen-activated protein (ERK1/2). Aspirin, an anti-inflammatory drug, is a known ERK inhibitor and prevents… CONTINUE READING

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