Prion pathogenesis in the absence of Toll-like receptor signalling.

Abstract

To reach the brain from peripheral sites, prions must colonize various cell types within the lymphoreticular compartment. However, no prion entry receptors are yet known. Toll-like receptors (TLRs) are pattern-recognition receptors that bind a multitude of pathogens and are therefore candidates as effectors of prion entry. Moreover, injection of… (More)

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Cite this paper

@article{Prinz2003PrionPI, title={Prion pathogenesis in the absence of Toll-like receptor signalling.}, author={Marco Prinz and Mathias Heikenwalder and Petra Schwarz and Kiyoshi Takeda and Shizuo Akira and Adriano Aguzzi}, journal={EMBO reports}, year={2003}, volume={4 2}, pages={195-9} }