Prion neuropathology follows the accumulation of alternate prion protein isoforms after infective titre has peaked

@inproceedings{Sandberg2014PrionNF,
  title={Prion neuropathology follows the accumulation of alternate prion protein isoforms after infective titre has peaked},
  author={Malin K. Sandberg and Huda Al-Doujaily and Bernadette Sharps and Michael Wiggins De Oliveira and Christian Schmidt and Angela C. Richard-Londt and Sarah Lyall and Jacqueline M. Linehan and Sebastian Brandner and Jonathan D F Wadsworth and A. R. Clarke and John Collinge},
  booktitle={Nature communications},
  year={2014}
}
Prions are lethal infectious agents thought to consist of multi-chain forms (PrP(Sc)) of misfolded cellular prion protein (PrP(C)). Prion propagation proceeds in two distinct mechanistic phases: an exponential phase 1, which rapidly reaches a fixed level of infectivity irrespective of PrP(C) expression level, and a plateau (phase 2), which continues until clinical onset with duration inversely proportional to PrP(C) expression level. We hypothesized that neurotoxicity relates to distinct… CONTINUE READING
Recent Discussions
This paper has been referenced on Twitter 1 time over the past 90 days. VIEW TWEETS

Citations

Publications citing this paper.
Showing 1-10 of 38 extracted citations

References

Publications referenced by this paper.

Similar Papers

Loading similar papers…