Prion-like properties of disease-relevant proteins in amyotrophic lateral sclerosis

@article{Bruer2018PrionlikePO,
  title={Prion-like properties of disease-relevant proteins in amyotrophic lateral sclerosis},
  author={S. Br{\"a}uer and V. Zimyanin and A. Hermann},
  journal={Journal of Neural Transmission},
  year={2018},
  volume={125},
  pages={591-613}
}
  • S. Bräuer, V. Zimyanin, A. Hermann
  • Published 2018
  • Biology, Medicine
  • Journal of Neural Transmission
  • The hallmark of age-related neurodegenerative diseases is the appearance of cellular protein deposits and spreading of this pathology throughout the central nervous system. Growing evidence has shown the involvement and critical role of proteins with prion-like properties in the formation of these characteristic cellular aggregates. Prion-like domains of such proteins with their proposed function in the organization of membraneless organelles are prone for misfolding and promoting further… CONTINUE READING
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