Prion-like domains as epigenetic regulators, scaffolds for subcellular organization, and drivers of neurodegenerative disease

@inproceedings{March2016PrionlikeDA,
  title={Prion-like domains as epigenetic regulators, scaffolds for subcellular organization, and drivers of neurodegenerative disease},
  author={Z. Marshall March and Oliver D. King and James Shorter},
  booktitle={Brain Research},
  year={2016}
}
Key challenges faced by all cells include how to spatiotemporally organize complex biochemistry and how to respond to environmental fluctuations. The budding yeast Saccharomyces cerevisiae harnesses alternative protein folding mediated by yeast prion domains (PrDs) for rapid evolution of new traits in response to environmental stress. Increasingly, it is appreciated that low complexity domains similar in amino acid composition to yeast PrDs (prion-like domains; PrLDs) found in metazoa have a… CONTINUE READING
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