Prion-like acceleration of a synucleinopathy in a transgenic mouse model.

  title={Prion-like acceleration of a synucleinopathy in a transgenic mouse model.},
  author={Anne-Laure J Mougenot and Simon Nicot and Anna A. Bencsik and Eric Morignat and J{\'e}r{\'e}my Verch{\`e}re and Latefa Lakhdar and St{\'e}phane Legastelois and Thierry Baron},
  journal={Neurobiology of aging},
  volume={33 9},
Our aim in this study was to investigate experimentally the possible in vivo transmission of a synucleinopathy, using a transgenic mouse model (TgM83) expressing the human A53T mutated α-synuclein. Brain homogenates from old TgM83 mice showing motor clinical signs due to the synucleinopathy and containing insoluble and phosphorylated (pSer129) α-synuclein were intracerebrally inoculated in young TgM83 mice. This triggered an early onset of characteristic motor clinical signs, compared with… CONTINUE READING
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