Prion-inducing domain of yeast Ure2p and protease resistance of Ure2p in prion-containing cells.

@article{Masison1995PrioninducingDO,
  title={Prion-inducing domain of yeast Ure2p and protease resistance of Ure2p in prion-containing cells.},
  author={Daniel C Masison and Reed B Wickner},
  journal={Science},
  year={1995},
  volume={270 5233},
  pages={93-5}
}
The genetic properties of the [URE3] non-Mendelian element of Saccharomyces cerevisiae suggest that it is a prion (infectious protein) form of Ure2p, a regulator of nitrogen catabolism. In extracts from [URE3] strains, Ure2p was partially resistant to proteinase K compared with Ure2p from wild-type extracts. Overexpression of Ure2p in wild-type strains induced a 20- to 200-fold increase in the frequency with which [URE3] arose. Overexpression of just the amino-terminal 65 residues of Ure2p… CONTINUE READING
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