Prion-induced and spontaneous formation of transmissible toxicity in PrP transgenic Drosophila.

Abstract

Prion diseases are fatal transmissible neurodegenerative diseases of various mammalian species. Central to these conditions is the conversion of the normal host prion protein PrP(C) into the abnormal prion conformer PrP(Sc). Mature PrP(C) is attached to the plasma membrane by a glycosylphosphatidylinositol anchor, whereas during biosynthesis and metabolism… (More)
DOI: 10.1042/BJ20140129

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