Prion-forming ability of Ure2 of yeasts is not evolutionarily conserved.

  title={Prion-forming ability of Ure2 of yeasts is not evolutionarily conserved.},
  author={Herman K. Edskes and Abbi Engel and Lindsay M McCann and Andreas Brachmann and H F Tsai and Reed B Wickner},
  volume={188 1},
[URE3] is a prion (infectious protein) of the Saccharomyces cerevisiae Ure2p, a regulator of nitrogen catabolism. We show that wild S. paradoxus can be infected with a [URE3] prion, supporting the use of S. cerevisiae as a prion test bed. We find that the Ure2p of Candida albicans and C. glabrata also regulate nitrogen catabolism. Conservation of amino acid sequence within the prion domain of Ure2p has been proposed as evidence that the [URE3] prion helps its host. We show that the C. albicans… CONTINUE READING
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