Prion diseases of humans and farm animals: epidemiology, genetics, and pathogenesis.


Neuronal vacuolation (spongiosis), neuronal death, and pronounced glial reactions are the hallmarks of transmissible spongiform encephalopathies (TSEs), or prion diseases. A wealth of physical, biochemical, and immunological evidence indicates that the TSE agent, termed prion, does not contain agent-specific nucleic acid encoding its own constituents, as is… (More)

4 Figures and Tables


  • Presentations referencing similar topics