Prion and anti-codon usage: does infectious PrP alter tRNA abundance to induce misfolding of PrP?


The "protein-only" hypothesis of prion diseases views the infectious agent as devoid of nucleic acids and consisting of misfolded prion proteins (PrP(Sc)) which, upon infiltration into host cells, act as a template that induces transformation of wild-type protein (PrP(C)) to the pathological form by unknown mechanisms. The two isoforms are identical in… (More)
DOI: 10.1016/j.mehy.2008.07.051