Prion-Like Polymerization in Immunity and Inflammation.

  title={Prion-Like Polymerization in Immunity and Inflammation.},
  author={Xin Cai and Hui Xu and Zhijian J Chen},
  journal={Cold Spring Harbor perspectives in biology},
  volume={9 4}
The innate immune system relies on receptors that sense common signs of infection to trigger a robust host-defense response. Receptors such as RIG-I and NLRP3 activate downstream adaptors mitochondrial antiviral signaling (MAVS) and apoptosis-associated speck-like protein (ASC), respectively, to propagate immune and inflammatory signaling. Recent studies have indicated that both MAVS and ASC form functional prion-like polymers to propagate immune signaling. Here, we summarize the biochemical… CONTINUE READING
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