Principles of therapy for congestive heart failure.


Vascular smooth muscle differs from myocardial tissue in several critical ways: (1) calcium ion entry is achieved by at least two channels; (2) both alpha-1 and alpha-2 postjunctional receptors regulate vascular tone; (3) calmodulin increases the activity of the myosin light chain kinase; (4) cyclic AMP decreases rather than increases cytosolic calcium ion… (More)


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