Principles of systemic antimicrobial therapy in foreign material associated infection in bone tissue, with special focus on periprosthetic infection.

@article{Frommelt2006PrinciplesOS,
  title={Principles of systemic antimicrobial therapy in foreign material associated infection in bone tissue, with special focus on periprosthetic infection.},
  author={Lars Frommelt},
  journal={Injury},
  year={2006},
  volume={37 Suppl 2},
  pages={S87-94}
}
Foreign material associated infection in bone tissue is mostly characterized by the features of sessile pathogens acting from the foreign material surface. These bacteria protected by biofilm attached to the surface are highly resistant for antimicrobial agents and host's own defense as well. Therapy is based on surgical revision, with removal of the foreign material and supplementary antimicrobial therapy. Empirical antimicrobial therapy cannot be recommended unless life threatening septicemia… CONTINUE READING
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