Principles of selective ion transport in channels and pumps.

@article{Gouaux2005PrinciplesOS,
  title={Principles of selective ion transport in channels and pumps.},
  author={Eric Gouaux and Roderick MacKinnon},
  journal={Science},
  year={2005},
  volume={310 5753},
  pages={
          1461-5
        }
}
  • Eric Gouaux, Roderick MacKinnon
  • Published in Science 2005
  • Medicine, Chemistry
  • The transport of ions across the membranes of cells and organelles is a prerequisite for many of life's processes. Transport often involves very precise selectivity for specific ions. Recently, atomic-resolution structures have been determined for channels or pumps that are selective for sodium, potassium, calcium, and chloride: four of the most abundant ions in biology. From these structures we can begin to understand the principles of selective ion transport in terms of the architecture and… CONTINUE READING

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