Principles of pharmacotherapy.


This chapter will review the challenges in pharmacotherapy in primary brain tumors that include the presence of the blood-brain barrier, a blood-tumor barrier, active drug efflux pumps, and high plasma protein binding of agents. The approaches to improve the delivery of drugs to the brain will be discussed. Often the management of brain tumors involves the use of corticosteroids and enzyme-inducing antiseizure medications that can have significant drug interactions that may impact the efficacy or toxicity of drugs used to treat these patients. Various techniques used to assess drug distribution to the brain will be reviewed.

DOI: 10.1016/B978-0-12-802997-8.00009-8

Cite this paper

@article{Batchelor2016PrinciplesOP, title={Principles of pharmacotherapy.}, author={Tracy Batchelor and Jordi A Rodon and Manmeet Singh Ahluwalia}, journal={Handbook of clinical neurology}, year={2016}, volume={134}, pages={149-62} }