Principles of microRNA regulation of a human cellular signaling network

  title={Principles of microRNA regulation of a human cellular signaling network},
  author={Qinghua Cui and Zhenbao Yu and Enrico O. Purisima and Edwin Wang},
  journal={Molecular Systems Biology},
  pages={46 - 46}
MicroRNAs (miRNAs) are endogenous approximately 22-nucleotide RNAs, which suppress gene expression by selectively binding to the 3'-noncoding region of specific messenger RNAs through base-pairing. Given the diversity and abundance of miRNA targets, miRNAs appear to functionally interact with various components of many cellular networks. By analyzing the interactions between miRNAs and a human cellular signaling network, we found that miRNAs predominantly target positive regulatory motifs… CONTINUE READING

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