Principles of ion recognition in RNA: insights from the group II intron structures.


Metal ions promote both RNA folding and catalysis, thus being essential in stabilizing the structure and determining the function of large RNA molecules, including group II introns. The latter are self-splicing metalloribozymes, containing a heteronuclear four-metal-ion center within the active site. In addition to these catalytic ions, group II introns… (More)
DOI: 10.1261/rna.043414.113


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