Principles of interleukin (IL)-6-type cytokine signalling and its regulation.

  title={Principles of interleukin (IL)-6-type cytokine signalling and its regulation.},
  author={Peter Claus Heinrich and Iris Behrmann and Serge Haan and Heike M Hermanns and G M{\"u}ller-newen and Fred Schaper},
  journal={The Biochemical journal},
  volume={374 Pt 1},
The IL (interleukin)-6-type cytokines IL-6, IL-11, LIF (leukaemia inhibitory factor), OSM (oncostatin M), ciliary neurotrophic factor, cardiotrophin-1 and cardiotrophin-like cytokine are an important family of mediators involved in the regulation of the acute-phase response to injury and infection. Besides their functions in inflammation and the immune response, these cytokines play also a crucial role in haematopoiesis, liver and neuronal regeneration, embryonal development and fertility… CONTINUE READING
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  • J. Immunol
  • 2003

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