Principles of blood irradiation, dose validation, and quality control

@article{Moroff1997PrinciplesOB,
  title={Principles of blood irradiation, dose validation, and quality control},
  author={Gary Moroff and Susan F. Leitman and N L Luban},
  journal={Transfusion},
  year={1997},
  volume={37}
}
he use of irradiated blood components to prevent graft-versus-host disease in susceptible patients has increased dramatically in the past sevT eral years. Irradiation eliminates the proliferative capacity of lymphocytes present in red cell, platelet, and freshly collected plasma component^.'-^ After penetrating blood components, the photons delivered by a radiation beam cause the formation of electrically charged particles or secondary electrons. These electrons damage the DNA of lymphocytes… 

[Evaluation of absorbed dose-distribution in the X-ray or gamma-irradiator for blood products].

TLDR
Using blood-compatible materials, a careful dose calibration study should be employed in which the absorbed dose of 15 Gy is obtained at the point where the lowest dose could be expected, which may lead to substantial underexposure of the blood products.

Irradiation of Blood Products

Prevention of Transfusion-Associated Graft-versus-Host Disease by Irradiation: Technical Aspect of a New Ferrous Sulphate Dosimetric System

TLDR
A dosimetric system based on the standard Fricke Xylenol Gel (FXG) dosimeter and an appropriate phantom is proposed and a linear response for absorbed doses up to 54 Gy was obtained with this system.

The in vitro quality of X‐irradiated platelet components in PAS‐E is equivalent to gamma‐irradiated components

TLDR
In vitro quality of platelet components (pooled and apheresis) following X‐ or gamma‐irradiation is examined following gamma irradiation to inactivate lymphocytes.

The effect of gamma radiation on the lipid profile of irradiated red blood cells

TLDR
Although gamma irradiation is the main agent for the prevention of TA-GVHD, a better understanding of the physical and biochemical properties of erythrocytes are necessary to better assess their viability, and to be able to issue more secure recommendations on the shelf life of blood bags, and the safe use of the irradiated red cells therein.

Dosimetry of gamma chamber blood irradiator using PAGAT gel dosimeter and Monte Carlo simulations

TLDR
PAGAT gel dosimetry is a reliable method for dosimetric of the blood irradiator and is capable of 3D dose calculation, according to the results obtained in this study.
...

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TLDR
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TLDR
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TLDR
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TLDR
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TLDR
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TLDR
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