Principles of antibody-mediated TNF receptor activation

@inproceedings{Wajant2015PrinciplesOA,
  title={Principles of antibody-mediated TNF receptor activation},
  author={Harald Wajant},
  booktitle={Cell Death and Differentiation},
  year={2015}
}
From the beginning of research on receptors of the tumor necrosis factor (TNF) receptor superfamily (TNFRSF), agonistic antibodies have been used to stimulate TNFRSF receptors in vitro and in vivo. Indeed, CD95, one of the first cloned TNFRSF receptors, was solely identified as the target of cell death-inducing antibodies. Early on, it became evident from in vitro studies that valency and Fcγ receptor (FcγR) binding of antibodies targeting TNFRSF receptors can be of crucial relevance for… CONTINUE READING
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