Principles of adoptive T cell cancer therapy.

  title={Principles of adoptive T cell cancer therapy.},
  author={Carl H June},
  journal={The Journal of clinical investigation},
  volume={117 5},
  • Carl H June
  • Published 2007 in The Journal of clinical investigation
The transfusion of T cells, also called adoptive T cell therapy, is an effective treatment for viral infections and has induced regression of cancer in early-stage clinical trials. However, recent advances in cellular immunology and tumor biology are guiding new approaches to adoptive T cell therapy. For example, use of engineered T cells is being tested as a strategy to improve the functions of effector and memory T cells, and manipulation of the host to overcome immunotoxic effects in the… CONTINUE READING