Principles of Selective Ion Transport in Channels and Pumps

@article{Gouaux2005PrinciplesOS,
  title={Principles of Selective Ion Transport in Channels and Pumps},
  author={E. Gouaux and R. MacKinnon},
  journal={Science},
  year={2005},
  volume={310},
  pages={1461 - 1465}
}
The transport of ions across the membranes of cells and organelles is a prerequisite for many of life's processes. Transport often involves very precise selectivity for specific ions. Recently, atomic-resolution structures have been determined for channels or pumps that are selective for sodium, potassium, calcium, and chloride: four of the most abundant ions in biology. From these structures we can begin to understand the principles of selective ion transport in terms of the architecture and… Expand

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