Principles of RNA compaction: insights from the equilibrium folding pathway of the P4-P6 RNA domain in monovalent cations.

@article{Takamoto2004PrinciplesOR,
  title={Principles of RNA compaction: insights from the equilibrium folding pathway of the P4-P6 RNA domain in monovalent cations.},
  author={Keiji Takamoto and Rhiju Das and Qin He and Sebastian Doniach and M. Brenowitz and Daniel Herschlag and Mark R. Chance},
  journal={Journal of molecular biology},
  year={2004},
  volume={343 5},
  pages={1195-206}
}
Counterions are required for RNA folding, and divalent metal ions such as Mg(2+) are often critical. To dissect the role of counterions, we have compared global and local folding of wild-type and mutant variants of P4-P6 RNA derived from the Tetrahymena group I ribozyme in monovalent and in divalent metal ions. A remarkably simple picture of the folding thermodynamics emerges. The equilibrium folding pathway in monovalent ions displays two phases. In the first phase, RNA molecules that are… CONTINUE READING

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