Principles of E-Cadherin Supramolecular Organization In Vivo

  title={Principles of E-Cadherin Supramolecular Organization In Vivo},
  author={Binh-An Truong Quang and Madhav Mani and O. M. Markova and Thomas Lecuit and Pierre-François Lenne},
  journal={Current Biology},
BACKGROUND E-cadherin plays a pivotal role in tissue morphogenesis by forming clusters that support intercellular adhesion and transmit tension. What controls E-cadherin mesoscopic organization in clusters is unclear. RESULTS We use 3D superresolution quantitative microscopy in Drosophila embryos to characterize the size distribution of E-cadherin nanometric clusters. The cluster size follows power-law distributions over three orders of magnitude with exponential decay at large cluster sizes… CONTINUE READING
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