Principles of Allostasis: Optimal Design, Predictive Regulation, Pathophysiology, and Rational Therapeutics.

@inproceedings{Sterling2004PrinciplesOA,
  title={Principles of Allostasis: Optimal Design, Predictive Regulation, Pathophysiology, and Rational Therapeutics.},
  author={P. Sterling},
  year={2004}
}
INTRODUCTION This chapter compares two alternative models of physiological regulation. The first model, homeostasis (“stability through constancy”), has dominated physiology and medicine since Claude Bernard declared, “All the vital mechanisms … have only one object – to preserve constant the conditions of … the internal environment.” His dictum has been interpreted literally to mean that the purpose of physiological regulation is to clamp each internal parameter at a “setpoint” by sensing… Expand
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References

SHOWING 1-10 OF 144 REFERENCES
Biological basis of stress-related mortality.
TLDR
The extraordinary sensitivity of the brain and the neuro-endocrine system to psychosocial intervention suggests that in modern, as in primitive society, these are the treatments that will prove safest and most effective. Expand
The inflammatory reflex
TLDR
The discovery that cholinergic neurons inhibit acute inflammation has qualitatively expanded understanding of how the nervous system modulates immune responses, and the opportunity now exists to apply this insight to the treatment of inflammation through selective and reversible 'hard-wired' neural systems. Expand
Drug Addiction, Dysregulation of Reward, and Allostasis
TLDR
The view that addiction is the pathology that results from an allostatic mechanism using the circuits established for natural rewards provides a realistic approach to identifying the neurobiological factors that produce vulnerability to addiction and relapse. Expand
The Need to Feed Homeostatic and Hedonic Control of Eating
TLDR
The role played in homeostatic regulation of feeding by systemic mediators such as leptin and ghrelin are examined, which act on brain systems utilizing neuropeptide Y, agouti-related peptide, melanocortins, orexins, and melanin concentrating hormone, among other mediators. Expand
The community of the self
TLDR
Physiology and computational biology now suggest that healthy dynamic stability arises through the combination of specific feedback mechanisms and spontaneous properties of interconnected networks. Expand
The Use of Psychosocial Stimuli to Induce Prolonged Systolic Hypertension in Mice
TLDR
The study demonstrated that social groupings of nonprimates can be used in the experimental approach to the role of psychosocial stimuli and the early environment in the etiology of human hypertension. Expand
Central nervous system control of food intake
TLDR
A model is described that delineates the roles of individual hormonal and neuropeptide signalling pathways in the control of food intake and the means by which obesity can arise from inherited or acquired defects in their function. Expand
Essential hypertension. Part I: definition and etiology.
TLDR
This review of current concepts regarding the definition, etiology, and treatment of essential hypertension is intended to aid the clinician in identifying those individuals at high risk who need to undergo evaluation and treatment, as well as in selecting optimal treatment strategies for hypertensive patients with comorbid conditions and/or target organ damage. Expand
Beneficial effects of leptin on obesity, T cell hyporesponsiveness, and neuroendocrine/metabolic dysfunction of human congenital leptin deficiency.
The wide range of phenotypic abnormalities seen in the leptin-deficient ob/ob mouse and their reversibility by leptin administration provide compelling evidence for the existence of multipleExpand
Chronic stress and obesity: A new view of “comfort food”
TLDR
It is proposed that people eat comfort food in an attempt to reduce the activity in the chronic stress-response network with its attendant anxiety, which may explain some of the epidemic of obesity occurring in the authors' society. Expand
...
1
2
3
4
5
...